How I cut my cholesterol and ApoB nearly 40% (no statin)

Here's the part most people miss. APOE4 doesn't just raise your numbers. It changes what they mean. ApoE is your body's main lipid taxi. ApoE3 and ApoE2 prefer small HDL particles; ApoE4 prefers large, triglyceride-rich VLDL, a different trafficking pattern entirely ( Husain et al. 2021 ). The result: APOE4 carriers tend to run higher cholesterol, and the largest Alzheimer's cohort in the world found total cholesterol significantly higher in carriers ( Dunk & Driscoll 2022 ). The finding that should change how you think about it: high total cholesterol is a stronger Alzheimer's risk factor in APOE4 carriers than in non-carriers. The authors called low total cholesterol "a critical aspect of preventative care for AD, particularly for APOE ε4 allele carriers." It cuts both ways. In 2025, Nature Medicine tracked 5,705 people and isolated APOE4/4 homozygotes as their own subtype. In that group, Mediterranean diet adherence modulated dementia-related metabolites more effectively than in the general population ( Liu et al. 2025 ). Translation: if you're APOE4/4, your food has more leverage, not less. So does every other lever.