Trials in West Virginia.
7 APOE4-relevant Alzheimer’s trials run in West Virginia — 3 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Excludes APOE4 homozygotes (4/4 carriers)NCT03671889ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
This study tests whether a focused-ultrasound device, guided by MRI, can safely and temporarily open the blood-brain barrier in people with probable…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- Drug trial, genotype not specified, ARIA riskNCT05026866A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
This trial tests donanemab, an anti-amyloid antibody given by infusion, against a placebo in people with no memory or thinking problems but signs of amyloid in…
- Symptomatic patients only, not 4-specificNCT05469009Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy
This early-stage study tests whether it is safe and doable to use a focused ultrasound device, guided by MRI, to temporarily open the blood-brain barrier while…
- Early Alzheimer's drug trial, not 4-specificNCT05531526Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This trial tests whether a pill called AR1001 can slow memory and thinking decline in people with early Alzheimer's, compared with a placebo. It also checks…
- Open to carriers, not 4-specificNCT05997030Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
This trial is testing whether low-intensity focused ultrasound, a non-invasive device that sends gentle sound waves into the brain, is safe and tolerable for…
- Open to carriers, genotype not requiredNCT07718906Neuromodulation for Behavioral Changes in Neurological Disorders
This trial is testing whether focused ultrasound — sound waves aimed at specific brain regions — can safely reduce agitation, irritability, and anxiety in…
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Educational, not medical advice. Trial decisions belong between you and your physician.