Trials in Iowa.
24 APOE4-relevant Alzheimer’s trials run in Iowa — 7 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Huntington's study, not APOE4-relatedNCT00051324Neurobiological Predictors of Huntington's Disease (PREDICT-HD)
PREDICT-HD is an observational study, not a drug test. It follows people who carry the Huntington's disease gene expansion but have no symptoms yet, tracking…
- Huntington's study, not about APOE4NCT01574053Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Enroll-HD is an observational study, meaning no drug or treatment is given. It follows people with Huntington's disease, and their relatives and controls,…
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Not Alzheimer's-focused, not APOE4-specificNCT02327845Phenotype, Genotype & Biomarkers in ALS and Related Disorders
This is an observational study, so nothing is being tested as a treatment. Researchers are looking at how the genes and symptoms of ALS and related conditions,…
- Unrelated to APOE4 riskNCT03754725Ferritin and Iron Burden in SAH sIRB
This trial is testing whether deferiprone, an oral drug that removes iron from the body, can reduce iron buildup in the brain after a ruptured brain aneurysm…
- Supplement study, genotype not specifiedNCT03954899Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
This study tests whether 5mg of over-the-counter melatonin, taken for nine months, shifts Alzheimer's-related biomarkers and thinking test scores compared with…
- Explicitly targets APOE4-related conditionNCT04049643Hearing Aid and Individuals With Cognitive Disorders
This pilot study is testing whether different ways of fitting hearing aids — by an audiologist, through a support service, or as a standalone device — can help…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- High ARIA risk for carriersNCT04437511A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
This Phase 3 trial tested donanemab, an anti-amyloid antibody drug, against placebo in people with early Alzheimer's disease. Researchers measured how well it…
- Lewy body drug trial, not APOE4-specificNCT04760860Terazosin for Dementia With Lewy Bodies
This small pilot trial is testing whether terazosin, an existing blood pressure and prostate drug, is tolerable for people with dementia with Lewy bodies.…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Drug trial, genotype not specified, ARIA riskNCT05026866A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
This trial tests donanemab, an anti-amyloid antibody given by infusion, against a placebo in people with no memory or thinking problems but signs of amyloid in…
- Anti-amyloid drug — carriers face higher ARIA riskNCT05463731A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1)
This Phase 3 trial is testing remternetug, an anti-amyloid antibody given by IV or injection under the skin, in people with early symptomatic Alzheimer's…
- Caregiver support, no APOE4 relevanceNCT05619263Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise
This trial is testing a behavioral program called Disaster PrepWise, designed to help family caregivers of people with dementia build emergency plans and…
- Not relevant to APOE4 or Alzheimer'sNCT05686551GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This trial is testing tominersen, a drug injected into the spinal fluid, against a placebo in people with prodromal or early Huntington's Disease. The goal is…
- Unrelated to APOE4 or Alzheimer'sNCT05707663Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
This observational study is tracking brain development in young people who have Juvenile-onset Huntington's Disease, a rare form that appears before age 21.…
- Open to carriers, not 4-specificNCT06223360A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
This trial is testing benfotiamine — a fat-soluble form of vitamin B1 — at two different doses against a placebo, in people who already have early Alzheimer's…
- Drug trial, APOE4 handling not statedNCT06653153A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
This trial tests remternetug, an anti-amyloid antibody drug, against a placebo. It measures how long it takes for memory, thinking, or daily-function problems…
- Unrelated to APOE4 or Alzheimer'sNCT06667414Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
This study is mapping specific genetic markers called SNPs in people who carry the Huntington's disease gene mutation. Participants give a blood sample and…
- Caregiver app study, not APOE4-specificNCT07032350E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
This study tests a web-based tool called the PACE-app, designed to help family caregivers manage pain in a loved one with dementia. Researchers will measure…
- General aging study, genotype not addressedNCT07224347Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is following older adults who were previously in the ASPREE aspirin trial to see what happens after they stopped taking aspirin. Researchers are…
- Unrelated to APOE4 or Alzheimer'sNCT07326709A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
This trial is testing votoplam, an oral drug designed to slow the progression of early-stage Huntington's disease. Researchers are comparing it against a…
- Prior participants only, not APOE4-specificNCT07602582A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
This Phase 3 trial tests whether people who already took donanemab in an earlier study (TRAILBLAZER-ALZ 3) get clinical benefit from yearly doses compared with…
- Open to carriers, not 4-specificNCT07796308Terazosin And Metabolic Engagement in Alzheimer's Disease
This trial tests terazosin, a drug already used for high blood pressure and enlarged prostate, in people with early Alzheimer's or MCI due to Alzheimer's.…
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Educational, not medical advice. Trial decisions belong between you and your physician.