Trials in Iowa.
13 APOE4-relevant Alzheimer’s trials run in Iowa — 5 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Unrelated to APOE4 riskNCT03754725Ferritin and Iron Burden in SAH sIRB
This trial is testing whether deferiprone, an oral drug that removes iron from the body, can reduce iron buildup in the brain after a ruptured brain aneurysm…
- Explicitly targets APOE4-related conditionNCT04049643Hearing Aid and Individuals With Cognitive Disorders
This pilot study is testing whether different ways of fitting hearing aids — by an audiologist, through a support service, or as a standalone device — can help…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- High ARIA risk for carriersNCT04437511A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
This Phase 3 trial tested donanemab, an anti-amyloid antibody drug, against placebo in people with early Alzheimer's disease. Researchers measured how well it…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Anti-amyloid drug — carriers face higher ARIA riskNCT05463731A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1)
This Phase 3 trial is testing remternetug, an anti-amyloid antibody given by IV or injection under the skin, in people with early symptomatic Alzheimer's…
- Caregiver support, no APOE4 relevanceNCT05619263Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise
This trial is testing a behavioral program called Disaster PrepWise, designed to help family caregivers of people with dementia build emergency plans and…
- Not relevant to APOE4 or Alzheimer'sNCT05686551GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This trial is testing tominersen, a drug injected into the spinal fluid, against a placebo in people with prodromal or early Huntington's Disease. The goal is…
- Unrelated to APOE4 or Alzheimer'sNCT05707663Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
This observational study is tracking brain development in young people who have Juvenile-onset Huntington's Disease, a rare form that appears before age 21.…
- Open to carriers, not 4-specificNCT06223360A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
This trial is testing benfotiamine — a fat-soluble form of vitamin B1 — at two different doses against a placebo, in people who already have early Alzheimer's…
- Unrelated to APOE4 or Alzheimer'sNCT06667414Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
This study is mapping specific genetic markers called SNPs in people who carry the Huntington's disease gene mutation. Participants give a blood sample and…
- General aging study, genotype not addressedNCT07224347Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is following older adults who were previously in the ASPREE aspirin trial to see what happens after they stopped taking aspirin. Researchers are…
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Educational, not medical advice. Trial decisions belong between you and your physician.