Rapamycin News: the longevity-drug forum,for APOE4 carriers
Rapamycin News is a free, ad-free forum where people who use or study rapamycin and other longevity drugs compare papers, lab results and doctor conversations. APOE4 comes up there almost every day.
Carriers use the forum to read new research early and to see how other people discuss it with their doctors. These threads hold most of the APOE4 conversation.
What the evidence says about rapamycin for APOE4 carriers
It is not proven to prevent Alzheimer’s in carriers. Phoenix grades the brain evidence C, from one small pilot study, and the side effects that matter most for carriers are well documented.
Grade C
Brain benefit, grade C. A small pilot in cognitively normal, middle-aged carriers reported better blood-flow, metabolic and immune measures (preprint, 2025). A trial of sirolimus (rapamycin) in carriers without symptoms is recruiting (NCT07728175).
Phoenix grades evidence from A (strongest) to D (weakest). This page gives no doses. It is education, not medical advice: rapamycin is a prescription drug, and any decision about it is one to make with your doctor. The doctor conversation kit helps you prepare, and the emerging therapies guide covers what else is in trials.
How Phoenix and Rapamycin News fit together
The forum is where the longevity-drug conversation happens. Phoenix is where APOE4 carriers track what they do about it.
Phoenix is the app and community where 750+ APOE4 carriers track what works. Members keep their bloodwork, read against APOE4-specific targets, next to every supplement, medication and habit they change, so each retest shows what moved. Whatever you read on the forum, you can bring the question to carriers who already tried it, and to your doctor with your own numbers.
Phoenix earns revenue only from your membership, never from anything we recommend. That's how Phoenix stays truly independent.
Works with what you already use
We partner with these companies to bring your data into one place, with an APOE4 lens
Phoenix brings in your data from Apple Health, Google Health Connect and 60+ apps and devices, and reads it through an APOE4 lens.
Apple HealthiPhone
Google Health ConnectAndroid
(soon)
Samsung Health
(soon)
Sleep Cycle
Xiaomi
And 52 more apps that sync through Apple Health and Google Health Connect
A free, ad-free online forum about rapamycin and other longevity drugs. Readers share research summaries, lab results and what they discussed with their doctors. On 29 Oct 2026 it held more than 10,500 topics and 206,000 posts.
Is Rapamycin News free?
Yes. Reading is free and there are no ads. Posting needs a free account.
Does rapamycin prevent Alzheimer’s in APOE4 carriers?
That is not proven. Phoenix grades the brain evidence C: one small pilot study in middle-aged carriers reported better blood-flow, metabolic and immune measures, and a larger trial in carriers is recruiting. Rapamycin is a prescription drug, so talk with your doctor before starting it.
Which side effects matter most for APOE4 carriers?
Blood fats and blood sugar. Rapamycin raises triglycerides (evidence grade A) and can raise LDL and glucose (grade B). Carriers already watch these numbers, so test them before and during any change and review them with your doctor.
Where are the APOE4 discussions on the forum?
Search the forum for “APOE4”, or start with the threads listed on this page. The largest is “Predicting and Preventing Alzheimer’s & Dementia”.
Does Phoenix sell rapamycin or recommend a pharmacy?
No. Phoenix does not sell any drug and does not recommend any pharmacy. Phoenix earns revenue only from your membership, never from anything we recommend. That's how Phoenix stays truly independent.
Phoenix partner · Rapamycin News
Apple Health iPhone
Google Health Connect Android
(soon)
Samsung Health
(soon)
Sleep Cycle
Xiaomi