NCT07906769 · RECRUITING
Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models
Sponsor: Istituti Clinici Scientifici Maugeri SpA
This study uses AI to analyze how people speak during remote memory and thinking tests. The goal is to find speech patterns that could help diagnose Alzheimer's and related conditions earlier and tell them apart. It is a non-drug, speech-based study with no assigned phase, and the tool is still being built and tested.
Eligibility criteria
Participants with neurodegenerative diseases Inclusion criteria Diagnosis of mild cognitive impairment due to Alzheimer's disease (AD), primary progressive aphasia (PPA), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB), or Parkinson's disease (PD). Age 40-85 years. Italian native speaker. Able to provide informed consent. Exclusion criteria Mini-Mental State Examination (MMSE) score below 15. Other neurological or psychiatric diagnoses, including cerebrovascular disease documented by MRI or CT. Severe, uncorrected hearing or visual impairment. Clinical Dementia Rating (CDR) score above 1. Healthy controls Inclusion criteria Italian native speaker. Matched to the patient groups for age, sex, and education level. Exclusion criteria History of systemic, neurological, or psychiatric disease. Substance abuse. Family history of neurodegenerative disease. MMSE score below 27/30.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-30