NCT07652775 · RECRUITING
rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
This trial is testing whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique — combined with stationary cycling improves thinking, mood, sleep, and physical function in older adults who have both mild cognitive impairment and depression. Participants are randomly assigned to rTMS alone, rTMS plus cycling, or a sham (inactive) rTMS plus cycling. Phase NA means this is a practical intervention study, not a drug approval trial.
You may qualify if
- Aged 65 to 90 years.
- Diagnosed with mild cognitive impairment (MCI) according to established clinical criteria.
- Presence of depressive symptoms as determined by clinical assessment and Beck Depression Inventory-II (BDI-II).
- Able to communicate and follow study instructions.
- Able to ambulate independently with or without an assistive device.
- Able to provide written informed consent.
You're excluded if
- Diagnosis of dementia.
- History of epilepsy or seizure disorder.
- Presence of metallic implants, pacemakers, cochlear implants, or other contraindications to transcranial magnetic stimulation.
- Major neurological disorders, including stroke, Parkinson's disease, traumatic brain injury, or other neurodegenerative diseases.
- Severe psychiatric disorders other than depression.
- Severe cardiovascular, musculoskeletal, or medical conditions that preclude participation in aerobic exercise.
- Severe visual or hearing impairments that interfere with cognitive assessment.
- Current participation in another intervention study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-17