Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment

Eligibility criteria

We will include participants who: 1) are aged >60; 2) are living independently in the community; 3) have normal or corrected-to-normal vision and hearing; 4) read, write, and speak English fluently; 5) are right-handed (if participating in the MRI component); 6) have subjective feelings of memory decline in the past five years; 7) have telephone Montreal Cognitive Assessment (T-MoCA) scores \<19/22; 8) have high independence, as indicated by Instrumental Activities of Daily Living (IADL) scale >6/8; 9) have a Geriatric Depression Scale (GDS) score \<6/15; 10) are able to exercise at a moderate pace using resistance training for 60 minutes 3x/week; and 11) receive clearance from a physician to participate in an exercise program at baseline.
We will exclude participants who: 1) cannot partake or commit to exercise training 3x/week for 26 weeks or have engaged in resistance training >1x/week over the past three months; 2) cannot partake or commit to consuming a daily supplement for 26 weeks or have consumed nutritional supplements containing creatine monohydrate over the past three months; 3) have a known allergy to creatine monohydrate or dextrose; 4) have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease); 5) have pre-existing kidney disease, heart disease, or liver abnormalities; 6) have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety); 7) are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or 8) are ineligible or uncomfortable with blood sampling.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-08-20