NCT07799584 · RECRUITING
Temporal Interference Stimulation Combined With Tai Chi for Mild Cognitive Impairment
This study combines a brain stimulation technique called temporal interference stimulation with Tai Chi training in people with mild cognitive impairment, to see if it improves memory, thinking, and the ability to walk while multitasking. Some participants get real stimulation, others sham. It's an early-stage study — testing whether it works, not yet proven.
You may qualify if
- Age 60-80 years
- Community-dwelling
- Montreal Cognitive Assessment (MoCA) score \< 26
- Clinical Dementia Rating (CDR) score = 0.5
- Activities of Daily Living (ADL) score \< 26 (largely intact daily function)
- Does not meet criteria for dementia diagnosis (based on DSM-5 or NIA-AA criteria)
- No contraindications for MRI examination (no metallic implants, no claustrophobia)
- Able to provide written informed consent
You're excluded if
- Neurological conditions that may cause cognitive decline (e.g., cerebrovascular disease, encephalitis, Parkinson's disease, Huntington's disease)
- Severe visual, auditory, or language impairments preventing completion of neuropsychological assessments
- Severe depression (Geriatric Depression Scale > 10) or other major psychiatric disorders
- History of seizures or epilepsy
- Previous deep brain stimulation or electroconvulsive therapy within 6 months
- Alcohol or substance dependence
- Concurrent participation in another interventional clinical trial
- Contraindications for non-invasive brain stimulation: electronic or ferromagnetic implants, non-MRI compatible metal implants, history of seizures, pregnancy
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-09-02