NCT07122908 · Phase 1 · RECRUITING
The Effect of Repetitive Transcranial Magnetic Stimulation on Cognitive Improvement in Dementia With Lewy Bodies
This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a device that sends magnetic pulses through the scalp, is safe and feasible for people with Lewy body dementia. It targets the visual area at the back of the brain and looks at thinking and cognition. It is a Phase 1 trial, an early step that is not yet proven or approved.
You may qualify if
- Over 65 years of age
- Meeting the criteria for Probable DLB as proposed in the 2017 DLB diagnostic criteria
- Scoring between 0.5 and 1 on the Clinical Dementia Rating Scale (CDR)
You're excluded if
- If other causes of cognitive impairment are suspected, such as neurosyphilis, hypothyroidism, hyperthyroidism, metabolic encephalopathy, brain tumor, acute cerebral hemorrhage, acute cerebral infarction, previous territorial or strategic cerebral infarction, Wernicke's encephalopathy, or severe white matter hyperintensity detected in hematological tests, brain MRI, etc.
- If cooperation for interviews and self-assessment is difficult (e.g., due to hearing impairment, language disorders, severe psychotic conditions)
- If there is a history of psychiatric disorders: major affective disorder, schizophrenia, or schizo-affective disorder
- If electroencephalography (EEG) cannot be performed
- If epileptiform EEG findings are present or if the patient is currently receiving antiepileptic drugs.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-14