Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment

Eligibility criteria

Inclusion Criteria:
* Adults aged 60 to 75 years.
* Presence of mild cognitive impairment (MCI) determined by neuropsychological testing, meeting at least two of the following three established cutoff criteria:
* Montreal Cognitive Assessment (MoCA): 19-26 points.
* Memory Alteration Test (M@T): 28-37 points.
* Mini-Mental State Examination (MMSE): 12-24 points.
* Ability and willingness to provide written informed consent; consent may be provided by a family member or legal representative when necessary.
Exclusion Criteria:
* Previous diagnosis of severe cognitive impairment, Alzheimer disease, vascular dementia, or another neurodegenerative disorder affecting cognition.
* History of cerebral ischemia, cerebrovascular events, traumatic brain injury, or advanced-stage renal disease.
* Diagnosis of type 2 diabetes mellitus.
* Diagnosed dysbiosis or inflammatory bowel disease, including ulcerative colitis or Crohn disease.
* Use of antibiotics, laxatives, probiotics, or prebiotics within the 3 months prior to enrollment.
* Habitual consumption of fermented foods or fiber-rich supplements, particularly fiber intake >18 g/day.
* Excessive alcohol consumption, defined as ≥2 alcoholic drinks per day, or history of alcohol dependence.
* Chronic use of medications that may interfere with the microbiota-gut-brain axis, including immunosuppressants, antipsychotics, or corticosteroids.
* Recent surgery within the previous 3 months or a planned medical intervention during the study period.
* Known adverse reaction or hypersensitivity to any component of the synbiotic or to almond powder.
* Uncontrolled chronic stress identified by clinical assessment.
* Participation in intense physical activity or high-performance sports during the study.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-09-14