NCT05597410 · RECRUITING
Shanghai At Risk for Alzheimer's Disease: a Cohort Study
This is an observational study in Shanghai, not a drug or treatment test. Researchers follow adults 50 and older who have a parent, child, or sibling with Alzheimer's. They track memory and thinking changes over time and look at which lifestyle and environmental factors affect who develops Alzheimer's. No phase is listed.
Eligibility criteria
Inclusion Criteria: 1. the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband; 2. not patients with dementia; 3. ≥ 50 years, males and females; 4. subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years; 5. subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection. Exclusion criteria: Individuals will be excluded if they have: 1. other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; 2. history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition); 3. uncorrectable visual or auditory impairment that hampers the completion of related examination. 4. pre-menopausal women will also be excluded.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2022-10-28