NCT07768579 · RECRUITING
The Effect of Sequential Therapy on Alzheimer's Disease
This observational study is tracking how Alzheimer's disease progresses over 12 months across roughly 600 participants at different stages, from mild cognitive impairment through severe dementia. Researchers will measure changes in memory, daily function, behavior, and traditional Chinese medicine symptom patterns. Some participants will receive stage-based traditional Chinese medicine treatment; others will not. Because no phase is listed, this is an observational study, not a controlled drug trial.
You may qualify if
- Age 55 to 85 years, regardless of sex.
- Memory decline reported by the participant or family member for at least 6 months.
- Meets the diagnostic criteria for the target disease and is clinically diagnosed with mild cognitive impairment due to Alzheimer's disease or mild, moderate, or severe Alzheimer's dementia.
- Able to complete clinical scale assessments and blood sampling.
- Able to undergo brain magnetic resonance imaging (MRI) or amyloid-beta positron emission tomography (Aβ-PET) examinations using the tracers specified in the study protocol.
- Written informed consent provided by the participant or a legally authorized representative.
- Able to complete study follow-up.
- Participants with a known allergy to components of the exposure medications will be assigned to the non-exposed group.
You're excluded if
- Cerebrovascular disease, traumatic brain injury, thyroid dysfunction, vitamin deficiency, or other diseases sufficient to cause cognitive impairment.
- Malignant tumors unrelated to the target disease, hematological diseases, severe psychiatric disorders, depression, or anxiety disorders.
- Severe dysfunction of major organs, including the heart, brain, liver, or kidneys.
- Infectious diseases, including HIV or HBV infection.
- Pregnancy, breastfeeding, or plans for pregnancy in the near future.
- Gastrointestinal diseases that may affect drug absorption.
- Use of medications affecting cognitive function within 4 weeks before enrollment.
- Recent participation in or current participation in another trial.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-17