NCT07762235 · NOT YET RECRUITING
High-Amplitude Functional Exercises in Older Adults With Mild Cognitive Impairment
This trial tests whether a specialized exercise program combining physical movement with mental tasks (called dual-task high-amplitude functional exercises) improves balance, mobility, and daily independence in older adults with mild cognitive impairment. It compares that program against a standard balance-and-mobility exercise routine. Both groups exercise four times a week for four weeks. This is a Phase NA study, meaning it is a straightforward comparison trial rather than a drug approval study.
You may qualify if
- Living independently/actively in a nursing home.
- Diagnosis of Mild Cognitive Impairment (MCI) based on a standardized screening test, with a Montreal Cognitive Assessment (MoCA) score of 18-25.
- Ability to walk independently for at least 10 meters without an assistive device or with only a cane/single-point support.
- Sufficient vision and hearing capacity to follow dual-task instructions and exercise directions, which may be corrected with glasses or hearing aids.
- Stable medical condition that does not prevent participation in the exercise program throughout the study.
You're excluded if
- Diagnosis of dementia or severe cognitive impairment based on cognitive screening (MoCA \<17).
- Neurological conditions that primarily affect balance, such as Parkinson's disease, residual effects of stroke, multiple sclerosis, or cerebellar ataxia.
- Severe osteoarthritis, active inflammatory joint disease, or a history of major orthopedic surgery within the previous 6 months that could limit exercise performance.
- Uncontrolled hypertension, heart failure (NYHA Class III-IV), or cardiopulmonary instability causing symptoms during exercise.
- Advanced vestibular pathology or severe loss of proprioception in the lower extremities that could be the primary cause of balance impairment.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-13