NCT07732842 · RECRUITING
Study of Repetitive Behaviors in Alzheimer's Disease
This study is not testing a drug or treatment. It is an observational study trying to understand why some Alzheimer's patients repeat the same actions or phrases over and over, while others do not. Researchers want to see whether poor memory updating, and a lack of awareness of one's own symptoms, might explain these repetitive behaviors. There is no phase — this is basic research, not a clinical intervention trial.
Eligibility criteria
Inclusion Criteria: I- RB+ (n=42) and RB- (n=30) groups : 1. MMSE > 20 2. 1 reliable family caregiver identified per patient 3. Patients under legal protection (guardianship/curatorship) or not 4. Selection: 4.a. AD patients with an SRI score > 0 will constitute the RB+ subgroup. 4.b. Only the first 30 patients included will undergo V2, V3, and V4. The first 30 AD patients included with an SRI score = 0 will constitute the RB- subgroup. II- Control group: healthy subjects (n=30) 1. Healthy subjects 2. MMSE ≥ 26/30 3. Men and women matched to AD patients in terms of age and sociocultural level. 4. Healthy subjects will be included by the CMRR in Limoges III- Control group: Patient with anterograde amnesia (AA) (n=1): 1. The patient with anterograde amnesia is a patient who participated in the ANISAAFORNIX study (another study submitted by the investigator) and is included in this study due to rich RB symptomatology. He is a 54-year-old man with lesions of the fornix following complications from neurosurgery, which led to severe anterograde amnesia. This patient does not have AD. 2. This patient is under legal protection (guardianship). 3. Patient monitored and included at the CMRR in Limoges. Exclusion Criteria: I- RB+ and RB- groups and healthy subjects: 1. Isolated participants (without an identified caregiver) (RB+ and RB- groups) 2. Participants must not have a history of alcohol or other substance dependence in the past 12 months. 3. Participants must not have any other neurological condition (with the exception of patients with AA anterograde amnesia). Any history of moderate to severe head trauma, stroke, or developmental disorders is a criterion for exclusion.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-07-29