Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention

Eligibility criteria

Inclusion Criteria :
* Aged between 50 and 75;
* Proficient or native speakers in French or English;
* Computer literate defined as being able to read mails and browse the Internet, and having access to a computer or tablet with an Internet connection;
* Eligible in at least one of the 3 intervention domains, where eligibility is defined as follows:
  * Low cognitive engagement in cognitively stimulating activities, defined as a score ≤ 22 on the adapted Cognitive Activity Questionnaire;
  * Low level of physical activity defined as less than 150 minutes/week) of moderate to vigorous physical activity measured using the Godin- Shephard Leisure Time Physical Activity Questionnaire, and no medical contraindication to physical activity based on the Physical Readiness Questionnaire for Everyone (PAR-Q+);
  * Low adherence to the Mediterranean-type diet defined as a score of ≤ 8 on the adapted Canadian Mediterranean Diet Scale, and no dietary restriction, severe allergy or intolerance or history of eating disorder.
Exclusion Criteria :
* Presence of a cognitive impairment as measured by the Creyos Dementia Assessment;
* General anesthesia within the last 6 months;
* Previous participation in the Luci program or in any validation studies related to the program;
* Current participation in another study;
* Unable to commit participation over the period of the study;
* Being in the precontemplation stage of change;
* High level of perceived stress;
* Having received a diagnosis of :
  * Dementia or neurodegenerative disease (AD and other dementias);
  * Past or present neurological disorder (multiple sclerosis, brain tumour, epilepsy, stroke, traumatic brain injury);
  * Severe psychiatric disorder (schizophrenia, major depression, bipolar disorder);
  * Diabetes or hypertension without medical monitoring;
  * Alcoholism or drug addiction;
  * Any other condition expected to limit participation (e.g., low visual acuity).

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-08-25