The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration

Eligibility criteria

Inclusion Criteria (patients):
* Adressed or followed at memory clinic or ALS expert center at Nantes university hospital.
* Aged 50-75 years
* Fulfilling current diagnosis criteria for one of the disorder: vcfFTD, non-Alzheimer PPA (semantic or non fluent), DCB or PSP,ALS
* MMSE ≥ 18
* Membership of social security scheme
Inclusion Criteria (healthy volunteers):
* No history of neurological disease, diabetes, or alteration/damage of peripheral nervous system
* Aged 50-75 years Paired to at least one patient on age (less or more 5 years)
* MOCA ≥ 26
* Membership of social security scheme
Non inclusion Criteria (Patients and healthy volunteers):
* Concomitting conditions affecting the peripheral nervous system such as but not limited to diabetes, renal failure, thyroid disorder, vitamin B12 deficiency, acute and chronic inflammatory diseases HIV, syphilis
* Know allergy to local anesthetic
* Known coagulopathy
* Pregnant women or breastfeeding women
* Person under court protection sous sauvegarde de justice
* Person under guardianship
* Inability to sign an informed consent
Non inclusion criteria (Patients) • Patient with neurological disease other than FTLD
Non inclusion criteria (Healthy volunteers) :
• Evidence of neurological disorder at the inclusion including but not limted to FTLD, Parkinson disease, Alzheimer disease, lewy body dementia, Huntington disease, systemic lupus erythematosus multiple sclerosis; learning disabilities, mental retardation, severe hypoxic brain injuries, brain trauma with permanent cognitive impairments.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2024-12-20