NCT07895979 · RECRUITING
The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
This trial tests whether a touchscreen virtual reality program simulating everyday tasks improves daily living skills and thinking, including memory and attention. It is compared with VR mini-games and tabletop cognitive training. Adults 50 and older take part, including people with memory concerns. Phase is not applicable because this is a behavioral study, not a drug trial.
Eligibility criteria
Inclusion Criteria: General Inclusion Criteria (Applicable to All Participants): * Aged 50 years or older. * Completed at least elementary school education (6 or more years of formal education) and able to read and write in Chinese. Group-Specific Inclusion Criteria: 1. Cognitively Healthy Middle-Aged and Older Adults Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 26. * Does not meet the diagnostic criteria for Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), or dementia. 2. Subjective Cognitive Decline (SCD) Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 23. * Subjective Cognitive Decline Questionnaire (SCD-Q) score > 7 (out of a total score of 24). * Answers "Yes" to both of the following questions: "Do you feel that you have memory problems compared to your previous normal state?" and "Have your family members or close friends noticed that you have memory problems compared to your previous state?" * Normal performance on standardized neuropsychological tests (Color Trails Test and memory-related tests), defined as scoring higher than 1.5 standard deviations below the age- and education-adjusted normative mean. * Does not meet the diagnostic criteria for Mild Cognitive Impairment (MCI) or dementia. 3. Mild Cognitive Impairment (MCI) Group: * Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 21. * Diagnosed with Mild Cognitive Impairment (MCI) by a neurologist or psychiatrist. * Does not meet the diagnostic criteria for dementia. Exclusion Criteria (Applicable to All Participants): * Meets the clinical diagnostic criteria for dementia. * Geriatric Depression Scale Short-Form (GDS-S) score >= 8, or cognitive changes caused by other psychiatric disorders, neurological diseases, or substance abuse with unstable medical conditions and interfering symptoms. * Severe visual or hearing impairments that prevent the completion of cognitive function assessments. * Physical illnesses or conditions that prevent participation in the cognitive and physical training interventions.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-26