NCT07883720 · RECRUITING
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
This study looks at what a single bike exercise session does to the brain. Researchers compare people with neurological conditions, including mild cognitive impairment and dementia, to healthy volunteers. They use brain MRI, blood draws, and autonomic measurements before and after. It is a one-day, early-stage study, not a test of a treatment.
You may qualify if
- 18 years or older
- Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor [for participants with neurological diseases]
- No diagnosis of neurological disease [for healthy control participants]
You're excluded if
- Non-english speaking individuals
- Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures)
- Current use of medications for cardiac rhythm or rate control
- Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-20