NCT07846189 · NOT YET RECRUITING
Rhythmic Entrainment and Alertness in Lewy Body Dementia
This study looks at how people with Lewy body dementia respond to rhythmic sound cues while tapping a finger, and whether alertness affects their ability to keep the beat. Researchers record brain activity with EEG during one visit. It is an early, non-drug study with no phase. It aims to guide future rhythm-based approaches, not to test a proven therapy.
You may qualify if
- Age 18 years or older
- Diagnosis of probable dementia with Lewy bodies (DLB) or mild cognitive impairment with Lewy bodies (MCI-LB) based on established clinical diagnostic criteria
- Fluent in English
- Able to attend with a study partner who can complete care-partner-reported cognitive fluctuation measures
- Clinical Dementia Rating (CDR) global score of 0.5-1.0
- Adequate upper-limb motor function, defined as Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III finger-tapping item (3.4) score ≤2 on at least one hand and ability to sustain rhythmic tapping for at least 10 seconds at approximately 1-3 Hz during a brief practice trial
- Adequate hearing, corrected if necessary, to perceive rhythmic auditory cues
- Stable on all medications for at least 30 days before enrollment
You're excluded if
- Age younger than 18 years
- CDR global score ≥2.0
- Severe upper-limb impairment, defined as MDS-UPDRS Part III finger-tapping item (3.4) score ≥3 in the dominant hand, or inability to produce more than 10 consecutive taps at ≥1 Hz despite instruction/practice
- Other neurological, musculoskeletal, or sensory conditions that preclude safe or reliable task participation
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-09