NCT07771036 · RECRUITING
Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment
This trial tests whether a single session of non-invasive brain stimulation aimed at the hippocampus — the brain's memory center — can sharpen memory and improve balance while walking in older adults with mild cognitive impairment. Researchers use electrical signals at 40 Hz delivered through the scalp and compare real stimulation to a sham (placebo) version. This is a Phase NA device study, meaning it is exploratory and not testing an approved treatment.
Eligibility criteria
1. Aged 65 years or older; 2. Presence of subjective memory complaints; 3. Objective cognitive impairment: screened using the Montreal Cognitive Assessment-Bejingversion (MoCA-BJ). The MoCA-BJ total score is 30 points. For individuals with \<12 years ofeducation, 1 point is added to the raw total score (corrected total score capped at 30 points); acorrected total score \<26 points indicates risk of cognitive impairment; 4. Clinical Dementia Rating (CDR) score of 0.5; 5. Does not meet diagnostic criteria for dementia: Mini-Mental State Examination (MMSE) scores>18 for illiterate individuals, 221 for those with primary school education, and >25 for those withjunior high school education or above;6. Retains independent activities of daily living (ADL) and is capable of cooperating with allassessments and interventions.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-18