Effects of Hydroxytyrosol-Rich Olive Polyphenol Dietary Supplement Combined With Mediterranean Diet Adherence on the Cognitive Health of Patients With Mild Cognitive Impairment

You may qualify if

• GR-based men and women aged 50 - 85
• Willingness and ability to conform to the full protocol.
• Ability to accept and sign the consent form.
• Presence of a diagnostic classification of Mild Cognitive Impairment according to the National Institute on Aging and Alzheimer's Association (NIA-AA) framework MCI, which corresponds to stage 3 on the pre-dementia range.
• MoCA score of ≥18 and ≤ 26. Or
• MMSE (Mini-Mental State Examination) score of ≥26 and ≤ 28.
• No active suicide ideation based on the Columbia-Suicide Severity Rating Scale.
• Absence of severe depressive symptomatology based on the Geriatric Depression Scale-15.
• Not using any laxative drugs for at least three days prior to the screening visit.
• Information about APOE status

You're excluded if

• Patients with mild, moderate, or severe dementia.
• Current or recent (within the last 4 weeks) engagement with a strict dietary regime i.e., vegetarian / vegan / ketogenic / paleolithic / high protein / weight loss.
• Any known issues with blood taking.
• Any known bleeding disorders.
• Any known allergy to olives, inability to tolerate gluten or multiple allergies/intolerances that would significantly limit food intake.
• Average alcohol use of >21 glasses per week for men and >14 glasses per week for women (on average for the last six months).
• History of psychiatric illness including intellectual disability, schizophrenia, bipolar disorder, severe, active depression and alcoholism.
• Neurologic conditions such as vascular dementia, movement disorders, history of conditions such as anaemia and cancer in the last five years, renal or liver failure, malignant tumours, or organ transplant.
• Coffee consumption greater than 5 cups per day.
• Body mass index > 35 kg/ m2.
• Not taking a stable dose of statins for at least 3 months before the recruitment visit. Taking antibiotics in the 1 week preceding the recruitment visit.
• Pregnancy or lactation.
• Participation in another clinical trial during the last 30 days prior to the recruitment visit.
• Subject taking supplements that may affect lipoprotein metabolism, >1 g of fish oil/day, antioxidant supplements, cannabidiol (CBD) oil.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-06-30