NCT07651787 · RECRUITING
Using Light Therapy for Mild Cognitive Impairment
This trial is testing whether a wearable light device — one that shines near-infrared light through the skull — can improve memory and brain blood flow in people with mild cognitive impairment. Half the participants get the real device, half get a sham version that looks identical. Researchers will also check blood markers of inflammation and brain cell stress. This is a Phase NA device trial, meaning it is exploratory and not yet proven effective.
You may qualify if
- Age: 55-95 years of age
- Clinical Dementia Rating (CDR) equal to 0.5 and/or Montreal Cognitive Assessment (MoCA) \<26 and ≥19
- Adequate hearing and visual acuity to participate in the examinations
- English speaker
- Presence of cerebrovascular pathology confirmed by structural brain imaging method
You're excluded if
- Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than TIA within 60 days prior to Visit 0
- Diagnosis of amyloid angiopathy
- Major psychiatric disease, including major depression not controlled on medications, alcohol or drug abuse
- Neurodegenerative diseases, e.g: Parkinson's, any kind of dementia
- Patients currently using commercial brain stimulation / neuromodulation device as part of a research study
- Patients currently take dietary supplements with an expected cerebrovascular benefit such as NAD- or NR-supplementum, L-citrullin, urolithin
- Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, hypertension uncontrolled by medication (>160/100 mmHg)
- Any other medical condition or medication which, in the opinion of investigator, would render the patient too unstable to complete the study protocol
- Severe sensory deficits interfering with the testing
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-16