NCT07560904 · RECRUITING
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
This study tests whether gentle electrical stimulation delivered through the scalp, aimed at a deep brain area called the striatum, can change working memory, attention, and planning skills. Researchers compare two stimulation frequencies against a control while using MRI. It is an early mechanism study with no phase, so it is not testing a proven or approved therapy.
You may qualify if
- normal cognitive performance as assessed by a cognitive screening for healthy subjects
- possible or probable MCI-LB or with PD-MCI, collectively called MCI-LBD, described as: presence of PD , and level II criteria for MCI (i.e. based on comprehensive neuropsychological examination), or the level II criteria for MCI , and at least two of four core DLB features including parkinsonism, visual hallucinations, attention/cognitive function fluctuation, and REM sleep behavioral disorder, or at least 1 core clinical feature and 1 indicative biomarker (probable MCI-LB).
You're excluded if
- Psychiatric disorders including major depression, major vascular lesions, or other brain pathologies that might present with cognitive decline.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-01