NCT07517380 · RECRUITING
Exercises for Rehabilitation of COgnition and Lifestyle Enhancement in Patients With Mild Cognitive Impairment
This trial tests whether a 12-week group program helps people with mild cognitive impairment (MCI). It combines brain-training exercises with lessons on lifestyle habits that protect the brain, using a web app. Researchers measure thinking, behavior, and daily function against a control group that gets an informational booklet. It is a small study of 40 people, and it has no drug phase.
You may qualify if
- Diagnosis of MCI according to the diagnostic criteria of Petersen (2004) and Winblad et al. (2004) and, if applicable (i.e., MCI due to AD), according to those of Albert and colleagues (2011).
- Self-reported basic skills in using technological devices, or access to a close person able to provide assistance.
- Willingness of the patient to report, during the study period, any changes in the dosage of psychotropic drugs or other medications that may affect cognition, such as anticholinergics, opioids, benzodiazepines, antidepressants, muscle relaxants, and antiepileptics.
You're excluded if
- Parkinson's disease.
- Linguistic single-domain MCI (suspected onset of primary progressive aphasia).
- Other neurological conditions potentially associated with cognitive impairment (e.g., previous stroke or traumatic brain injury).
- Significant laboratory abnormalities potentially associated with cognitive impairment (e.g., low levels of vitamin B12 or folate, or values indicative of thyroid disorders).
- Primary psychiatric disorders.
- Alcohol or substance use disorder in the previous 10 years.
- Severe behavioral disturbances limiting group participation.
- Hearing or visual impairments that may interfere with assessment or treatment.
- Medical conditions that may interfere with completion of the study.
- Exposure, during the study period, to other neuropsychological rehabilitation interventions.
- Patient's refusal to sign the informed consent.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-08