NCT07512193 · NOT YET RECRUITING
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment
This study tests a personalized brain stimulation device combined with computer-based memory training in people with mild cognitive impairment. Gentle electrical currents are tuned to each person's brain activity. Researchers will measure learning, memory, and brain connectivity over 6 to 8 weeks. It has no formal phase because it is a device study, mainly checking feasibility and early signs of benefit.
You may qualify if
- Must be between 45-85 years of age.
- Must be proficient in English.
- Must have a minimum of high-school education.
- Must be diagnosed with 'probable Alzheimer's Disease (AD)' in specialized diagnostic centers with neuropsychological (e.g., RAVLT) and AD biomarkers according to 2011 guidelines.
- The investigators will also perform extensive testing in the investigators' test battery including the Mnemonic Similarity Test (MST) that discriminates and measures the most salient hippocampal deficit-pattern separation (PS).
You're excluded if
- People with previous neurological disease including vascular dementia (e.g., stroke, developmental dyslexia, dysgraphia or attentional deficit).
- People with hearing loss (> 25 decibel, using audiometric hearing screen).
- People with uncorrected visual acuity loss.
- People with advanced dementia or severe language impairments (MMSE \<15, or Montreal Cognitive Assessment \<10, or language Frontotemporal Dementia-specific Clinical Dementia Rating (FTD-CDR) =3).
- People with pre-existing psychiatric disorders such as behavioral disturbances, severe depression, or schizophrenia that do not allow these people to comply or follow the study schedule and requirements such as repeated evaluation and therapy.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-07