NCT07304674 · RECRUITING
The Association Between Primary Aldosteronism and Cognitive Dysfunction
This is an observational study, meaning no drug or treatment is being tested. Researchers will follow people already diagnosed with primary aldosteronism, a hormone condition that causes high blood pressure, to see how common memory and thinking problems are and how they change over up to 5 years. It has no phase.
You may qualify if
- 1. Aged ≥ 40 years.
- 2. Biochemically confirmed diagnosis of Primary Aldosteronism (PA) according to contemporary guidelines (e.g., confirmed positive case detection test and confirmatory test).
- 3. Ability to understand and cooperate with comprehensive neuropsychological assessment.
- 4. Voluntary participation and provision of written informed consent.
You're excluded if
- 1. Significant visual, hearing, or motor impairment that prevents completion of cognitive testing.
- 2. History of major neurological disorders (e.g., stroke, Parkinson's disease, intracranial tumor, severe traumatic brain injury).
- 3. History of major psychiatric illness, intellectual disability, or current use of antipsychotic medications.
- 4. Diagnosis of secondary hypertension other than PA.
- 5. Unwillingness to participate by the patient or their legal representative.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-05