Neurocognitive Assessment Platform 4 Alzheimer

Eligibility criteria

Inclusion criteria common to both experimental groups:
* Signature of informed consent
* Age between 55 and 80 years
* Absence of functional impact on daily living activities or minimal impact on instrumental activities
Specfic inclusion criteria for Healthy Controls recruitment:
* Normal global cognitive efficiency (Mini Mental State Examination scores of 28 or higher)
* Absence of specific cognitive deficits (memory and other cognitive domains) that are abnormal for age, sex, and education level (1.5 standard deviations below the mean for age- and education-matched controls), as assessed by objective, standardized cognitive tests.
Specific inclusion criteria for aMCI recruitment:
* Cognitive difficulties reported by the individual, their family member, or their primary care physician
* Normal global cognitive efficiency (Mini Mental State Examination score within 0.5 standard deviations of the average for age- and education-matched control subjects).
* Specific cognitive deficits related to memory or multi-domain cognitive impairments (involving memory and other cognitive domains) that are atypical for the individual's age (1.5 standard deviations below the average for age- and education-matched controls), as determined by objective, standardized cognitive tests.
Exclusion Criteria:
* Rejection of informed consent
* Important sensory deficits (e.g., hearing loss or hypovisus)
* Current or previous history of psychiatric illness
* Current or previous degenerative pathology of the central nervous system (CNS)
* Presence of systemic diseases in anamnesis
* Presence of cerebrovascular events in anamnesis
* Use of alcohol or psychotropic substances in anamnesis

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-01-22