NCT07260253 · RECRUITING
Remotely-supervised Neuromodulation in PPA
This trial tests whether home-based brain stimulation (tDCS), combined with virtual speech therapy, helps people with logopenic primary progressive aphasia — a language disorder often caused by Alzheimer's — communicate better. It compares real stimulation to a sham version. This is an early-stage feasibility study, not proof it works yet.
You may qualify if
- Meets diagnostic criteria for primary progressive aphasia (PPA)
- Meets diagnostic criteria for logopenic variant PPA
- Attains score of 15 or higher on the Mini-Mental State Examination
- Has adequate hearing and vision (with hearing or vision aids, if needed)
- Is able to travel to research site and undergo MRI brain scan
- Has access to high speed internet and basic experience using a computer and the internet
- Is a fluent speaker of English
- Has a study partner who can co-enroll in the study, attend pre-treatment training at the research site, and be present for teleconference meetings, as needed
You're excluded if
- Speech and language deficits better accounted for by another neurological disorder
- Does not meet diagnostic criteria for logopenic variant PPA
- Scores less than 15 on the Mini-Mental State Examination
- Does not have a study partner who can co-enroll in the study
- Has contraindications for tDCS or MRI scan (History of seizures, head injury, craniotomy, skull surgery or fracture; History of severe or frequent migraines; Metallic implant in head or any metal in head; Pacemaker or cardioverter-defibrillator or any other stimulator; Chronic skin problems; Pregnancy)
- Has a history of stroke, epilepsy, or significant brain injury
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-09-04