NCT06869135 · RECRUITING
Saliva and Extracellular Vesicles for Neurodegenerative Diseases
This study is testing whether a simple saliva sample can help spot and track neurodegenerative diseases like Alzheimer's and Parkinson's. Researchers use a light-based technique called Raman spectroscopy to read the chemical makeup of saliva and tiny particles in it. Participants give saliva over time. The trial phase is unspecified, and this is a diagnostic test study, not a treatment.
You may qualify if
- AD: standard criteria for dementia due to AD with AD neurochemical demonstration.
- PD: MDS Criteria; modified Hoehn\&Yahr stages; stable pharmacological treatment (last 4 weeks).
- AtP: current consensus diagnostic criteria for progressive supranuclear palsy; corticobasal degeneration and multiple system atrophy.
- prodromic PD: according to diagnostic criteria by Berg;
- MCI: according to diagnostic criteria by Dubois and Albert.
You're excluded if
- For all the experimental groups considered, subjects with concomitant chronic and / or inflammatory diseases of the oral cavity, other systemic diseases, oncological or infectious diseases will be excluded.
- Patients not able to provide written informed consent autonomously will be excluded.
- For PD patients: Vascular, familiar and drug- induced parkinsonism, other known or suspected causes (metabolic, brain tumor etc) or any suggestive features of AtP; dementia with MoCA Test Correct Score\<15
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-07