NCT06734546 · RECRUITING
The Effect of Exercise on the Brain in Type 2 Diabetes
This trial tests whether six months of exercise, three times a week, helps the brain in people with type 2 diabetes. It compares high-intensity and moderate-intensity training against no exercise. Researchers measure brain metabolism, blood flow, and thinking skills using MRI scans, cognitive tests, and blood samples. It is not a drug trial and has no phase.
You may qualify if
- type 2 diabetes
- no insulin therapy
- 30-75 years old
- physically inactive
You're excluded if
- MRI contraindications
- psychological disorders
- exogenous insulin therapy
- history of coma, transient ischemic attack, head trauma, brain tumor, stroke, epilepsy, and other central nervous system diseases that could cause dementia or presence of dementia before T2DM
- suffering from any disease with significant impact on exercise intervention participation such as: chronic heart disease (e.g. valve insufficiency ≥ grade 2) or significant arrhythmias, cardiac events less than one year ago (myocardial infarction, coronary artery bypass graft, percutaneous coronary intervention), clinical heart failure (oedema, shortness of breath), percutaneous coronary intervention less than one year ago, chronic obstructive pulmonary disease (COPD), cerebrovascular or peripheral vascular disease
- severe hypertension (>160/110 mmHg)
- ongoing cancer, severe neuropathy (limiting exercise participation)
- renal disease (GRF \<45 ml/min/1,73 m2)
- inability to regularly participate in the exercise intervention
- pregnancy
- breastfeeding
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-31