NCT06179680 · RECRUITING
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This study uses routine brain MRI scans to measure white matter hyperintensities, which are bright spots on a scan that often show up in cognitive disorders. Researchers are looking at people with amnestic mild cognitive impairment or Alzheimer's, plus healthy comparison volunteers. It is an observational imaging study with no drug and no listed phase. The goal is better understanding, not a therapy.
You may qualify if
- Participants diagnosed with amnestic Mild Cognitive Impairment (aMCI) or Alzheimer's Disease (AD) based on clinical assessments.
- Individuals undergoing brain magnetic resonance imaging (MRI) at the IRCCS Policlinico San Donato as part of routine diagnostic procedures.
- Age-matched and gender-matched healthy control subjects for comparison.
You're excluded if
- Individuals with cognitive impairment other than amnestic MCI or AD.
- History of significant neurological disorders (other than MCI or AD) that may impact the study outcomes.
- Presence of contraindications for undergoing MRI procedures.
- Any serious medical or psychiatric condition that, in the judgment of the researchers, may interfere with the study participation or compromise the validity of the results.
- Known history of alcohol or substance abuse that may affect cognitive function.
- Inability or unwillingness to provide informed consent.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-07-09