NCT06052397 · RECRUITING
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
This observational study is tracking sleep patterns in adults age 70 and older before and after major orthopedic surgery, like hip or knee replacement. Researchers want to know whether disrupted sleep or circadian rhythms raise the risk of postoperative delirium and cognitive decline. It is not a drug trial — no treatment is being tested. Participants wear a wrist activity monitor for two weeks before surgery and give blood samples. Details on phase are not specified.
Inclusion criteria
- Age >= 70 years old
- Scheduled to undergo major orthopedic surgery
- Expected postoperative recovery of more than 24 hours as an inpatient
Exclusion criteria
- Cognitive impairment leading to inability to consent
- Patients with limited mobility or inability to wear an actigraphy watch
- Patients with infection at the site of actigraphy watch, allergies to materials of watch
- Patients with > two days in the ICU during the month prior to surgery
- Renal or liver failure
- Severe neurocognitive damage or history of psychiatric illness
- Blindness or deafness
- Patients who are non-English speaking
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-11