NCT05904132 · RECRUITING
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
This study tests whether a wearable brain stimulation device, using gentle 40 Hz electrical current timed to a person's own brain rhythms, can strengthen gamma brain waves and affect thinking performance. It enrolls people with mild cognitive impairment likely due to Alzheimer's. The trial compares real versus placebo stimulation. It is not a drug, and no phase applies.
You may qualify if
- Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported)
- 50-80 years of age
- English native speakers
You're excluded if
- Known presence of a structural brain lesion (e.g., tumor, cortical infarct)
- Acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure
- Active hematological, renal, pulmonary, endocrine or hepatic disorders
- Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
- tACS contraindications (lesions in the scalp, history of seizures)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-07-14