NCT05748613 · RECRUITING
Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
This trial tests a computer-based program that teaches people to feel less alarmed by anxious sensations, such as a racing heart. It looks at whether anxiety drops in older adults with mild memory problems or mild Alzheimer's, and whether stress eases for their care partners. It is compared with a health education program. Phase is not applicable, since it is a behavioral study, not a drug trial.
Eligibility criteria
Inclusion Criteria:
DYAD
* Patient age 60+
* Care partner 18+
* Has care partner who will participate ("someone you have a reciprocal relationship with who provides you with emotional or physical support and helps with decision-making. This could be a spouse or significant other, relative, or close friend whom you spend a significant amount of time with.")
* Has smartphone or access to Wi-Fi
EITHER
* Score of 20 or above on the PROMIS-Anxiety short form (patient only) OR
* Score of 5 or above on SSASI (patient only) OR
* Score of 31 or above on NIH Toolbox Perceived Stress Scale score (patient only)
AND EITHER
1. Participant MoCA score is between 17 to 26
OR
2. Participant Memory Complaint Scale score 3 or greater
OR
3. Care partner quick dementia rating scale score between 2 to 12.5
Exclusion Criteria:
PATIENT
* Issues with seeing or hearing that would prevent reading or listening to computer presentations
* Medical conditions that would preclude participation in study
* Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)
CARE PARTNER
* Issues with seeing or hearing that would prevent reading or listening to computer presentations
* Medical conditions that would preclude participation in study
* Severe mental illness (e.g., schizophrenia, unmedicated bipolar disorder)The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-05