NCT05540613 · RECRUITING
Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
This trial compares Tai Chi, conventional exercise, and a health education class over six months. It measures whether either type of movement improves thinking skills in older adults with mild cognitive impairment (MCI). It has no drug phase, since it tests a behavioral program. Participants are followed for six months after it ends.
Eligibility criteria
Inclusion Criteria: * Chinese older adults aged equal or larger than 50 years * Ethnic Chinese * MCI under criteria of Mayo Clinic, including the following i. people with subjective complaint about a decline in cognitive function. ii. total score in the Montreal Cognitive Assessment is equal or below the 7th percentile of the age- and education- corrected normative data of Hong Kong. iii. the decline in cognitive function does not impair daily functioning, as revealed by getting ≥2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living 4-point Scale). Exclusion Criteria: * medical history of major chronic diseases such as cancer, stroke, cerebro- and cardio-vascular diseases, and renal disease * uncontrolled diabetes * diagnosed with dementia or using anti-dementia medication * diagnosed with psychiatric diseases or using psychiatric medication * with diseases or on medications known to severely affect cognitive performance * somatic condition (e.g., limb lost) that prevent participation in exercise * impaired mobility by chronic diseases (e.g., neurological, musculoskeletal and autoimmune diseases) * incapable to perform physical exercise * regular exercise habit (>3 times 60-min Tai Chi or moderate-intensity conventional exercise weekly) in the past 3 months
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-11