Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease

You may qualify if

• Age 18 years or older with genetically confirmed Huntington's disease (HD) (cytosine-adenine-guanine [CAG] repeat expansion in the huntingtin [HTT] gene).
• Symptomatic HD, defined by a Unified Huntington's Disease Rating Scale (UHDRS) total motor score > 4, in early-intermediate stages according to Total Functional Capacity (TFC).
• Physical frailty and/or sarcopenia, defined as Short Physical Performance Battery (SPPB) score <= 10 and/or gait speed < 1.0 m/s and/or European Working Group on Sarcopenia in Older People 2 (EWGSOP2) sarcopenia criteria (low strength and low muscle quantity/quality assessed by validated bioelectrical impedance analysis (BIA)-derived indices).
• VIVIFRAIL category B (frail) or C1/C2 (pre-frail).
• Stable pharmacological treatment for at least 4 weeks before baseline.
• Clinical judgement of the neurologist and occupational therapist that the participant can safely perform a prescribed home-based exercise program with weekly remote monitoring.
• Written informed consent from the participant or legally authorized representative (with participant assent whenever possible).

You're excluded if

• Unstable cardiovascular, renal, hepatic or musculoskeletal disease contraindicating exercise or supplementation.
• Severe chorea or postural instability preventing safe training; uncontrolled psychiatric symptoms or active substance abuse.
• Severe dysphagia preventing safe intake of thickened liquids (unless a clinically acceptable alternative exists).
• Allergy or intolerance to any supplement component.
• Pregnancy or lactation.
• Use of protein supplements in the month before inclusion.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-10-28