NCT06626308 · RECRUITING
Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study
This small pilot study looks at whether brain functional MRI and a virtual reality gait test can pick up early signs of Huntington's disease in people who carry the gene but have no symptoms yet. Researchers compare them with healthy volunteers. It is an early-stage pilot, with no drug involved and no phase assigned.
You may qualify if
- 1. For PMGC: HD diagnosis confirmed by genetic testing (CAG triplets ≥36 in HTT gene); Unified Huntington Disease Rating Scale19 Total Motor Score (UHDRS-TMS) ≤ 5; age 18-70 years old. 2. For HC: normal neurological examination; age 18-70 years old.
You're excluded if
- Main exclusion criteria for both PMGC and HS will be: major ophthalmologic and psychiatric active diseases; cognitive impairment (Montreal Cognitive Assessment, MoCA score \< 25/30); gait issues related to non-neurological conditions; contraindications to brain MRI.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-20