NCT07842029 · RECRUITING

Evaluation of Blood-Based Biomarkers and Remote Cognitive Assessment for Dementia Triage (SANDBOX)

This study tests whether a blood test for Alzheimer's-related proteins, an APOE genetic test, and a recorded speech and memory assessment can help NHS Memory Clinics diagnose dementia faster. It's not testing a treatment, just whether these tools improve and speed up diagnosis. No phase specified, but this is an evaluation study, not a drug trial.

Eligibility criteria

Inclusion Criteria:
* The participant is willing and able to provide informed consent for participation in the study, or if unable to consent, a consultee (nearest of kin or holder of Power of Attorney) is available to make a declaration.
* Eligibility for recruitment in Scotland is restricted to participants who are able to provide informed consent themselves; participants requiring consultee consent will not be recruited in Scotland.
* Male or female, aged 50 years or older.
* The participant is currently on a waiting list for a participating Memory Clinic.
* The participant lives within traveling distance to a study site.
* The participant agrees to complete all study procedures, including genetic testing.
Exclusion Criteria:
* The participant may not enter the study if any of the following criteria apply:
* The participant has known or anticipated challenges with venous blood sampling.
* The participant is not fluent in English.
* The participant has a historical diagnosis of dementia.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-09-25

View full record on ClinicalTrials.gov

All APOE4 clinical trials