NCT07781657 · Phase 2 · NOT YET RECRUITING
Study to Test Effects and Safety of RO7568282 in Early Symptomatic Alzheimer's Disease
This trial tests a drug called RO7568282 against a placebo in people with mild cognitive impairment or mild dementia caused by confirmed Alzheimer's pathology. It's a Phase 2 study, meaning researchers are checking whether the drug works and is safe, not yet proven or approved for use.
Eligibility criteria
Inclusion Criteria: * Evidence of AD pathological process, as confirmed by either amyloid positron emission tomography (PET) scan or cerebrospinal fluid (CSF) * Mild cognitive impairment (MCI) or mild dementia due to AD * Able to swallow whole capsules * Body mass index (BMI) within the range of 18-34 kilograms per square metre (kg/m²) (at screening) * Availability of an appropriate study partner Exclusion Criteria: * Any evidence of a condition other than AD that may affect cognition * Participants must not have unstable or clinically significant cardiovascular disease within the last year, chronic uncontrolled hypertension, or clinically significant electrocardiogram (ECG) abnormalities * History or presence of clinically significant cerebrovascular disease * Clinically significant cerebral abnormalities on magnetic resonance imaging (MRI) Note: Other protocol-defined inclusion/exclusion criteria may apply.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-24