NCT07775833 · RECRUITING
Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community
This trial is testing whether eating golden oyster mushroom powder every day for 24 months helps protect thinking and memory in about 600 adults aged 45 to 80. Half get the mushroom powder, and researchers track cognitive test results over time. It's a dietary supplement study with no phase assigned, so the benefit is not yet proven.
You may qualify if
- (1) Community-living adult aged 45 years to 80 years, AND
- (2) Family history of Alzheimer's disease or having subjective cognitive (SCD) defined as "self-reported memory problems that have been getting worse over the past year.", AND
- (3) Consume mushrooms no more than once a week, AND
- (4) No dementia: CDR global score equal to zero.
You're excluded if
- (1) Any diagnosis of neurological diseases (e.g., epilepsy, stroke) made by a clinician, OR
- (2) Any diagnosis of psychiatric illnesses (e.g., depressive disorders) made by a clinician, OR
- (3) Significant sensory or motor impairments, OR
- (4) Known allergy to mushrooms or a history of serious food allergies, OR
- (5) Participants with a history of gout, OR
- (6) Diagnosed with hyperuricemia.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-09-01