NCT07657624 · NOT YET RECRUITING
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
This observational study is tracking people with coronary heart disease to see which risk factors are linked to cognitive decline. Researchers will use brain and heart scans, blood tests, sleep monitoring, and cognitive assessments on about 2,352 hospitalized patients in Beijing. No treatment is being tested — this is a study watching and measuring, not intervening. The phase is unspecified because it is an observational study, not a drug or device trial.
Eligibility criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. Diagnosis of coronary heart disease (meeting at least one of the following): * Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery; * Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment; * Objective evidence of myocardial ischemia or typical clinical symptoms 3. Completion of standardized neuropsychological assessment during hospitalization 4. Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments 5. Provision of signed written informed consent Exclusion Criteria: 1. Previously diagnosed dementia. 2. History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment. 3. Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder). 4. Pregnancy or breastfeeding.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-18