NCT07607756 · ACTIVE NOT RECRUITING
OCT-A Biomarkers for Cognitive Impairment in Patients With Chronic Atrial Fibrillation
This small pilot study uses a painless eye scan, called OCT angiography, to look at tiny blood vessels in the retina. Researchers will compare scans from people with atrial fibrillation who have memory and thinking problems against those who don't. It tests no drug. It's an early feasibility study, not a proven screening tool.
You may qualify if
- > 40 years old
- AF confirmed by cardiologist
- signed informed consent
You're excluded if
- history of stroke or thromboembolic event
- recent history of ocular surgery
- ocular diseases (severe cataract, glaucoma, macular degeneration, corneal ulcer, optic neuropathies)
- history of any systemic illness that may impact structure and microvasculature of the retina such as diabetes, hyperthyroidism, rheumatic disease, severe kidney injury, liver failure, advanced malignancy,
- OCT-A images of insufficient quality (due to artifacts)
- history of AF ablation
- major depression or other psychiatric/ neurodegenerative disorders
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-26