NCT07445841 · RECRUITING
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
This trial is testing whether a structured multimodal exercise program, started early after a stroke, can protect thinking and memory and reduce the risk of future cognitive decline and dementia. Researchers will track both cognitive performance and biological markers tied to dementia risk. This is a Phase NA trial, meaning it is a controlled study comparing the exercise program against a gentler balance and stretching routine, not yet a proven or approved intervention.
You may qualify if
- have had a first-ever ischemic/hemorrhagic stroke confirmed by MRI/CT 0-6 months prior to participation.
- Able to independently walk at least 10 meters (assistive devices permitted) and capable of following instructions will be required.
You're excluded if
- Diagnosed with dementia
- Medications that impact cognition
- Absolute contraindications to exercise or MRI scanning
- Significant disability (modified Rankin score >3)
- Participants will be excluded if they have been engaged in a structured exercise training program outside their regular in/out-patient hospital rehabilitation since suffering the stroke.
- Co-morbidities that preclude exercise participation, pain worsened with exercise, and communication (e.g., severe aphasia) or behavioral issues limiting safe participation will also be reasons for exclusion.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-26