NCT07192913 · Phase 2 · NOT YET RECRUITING
Glymphatic Function TMS Study
This study tests whether transcranial magnetic stimulation, a device that sends magnetic pulses through the scalp, can improve the brain's waste-clearance system, called the glymphatic system. Researchers will also check whether protein levels linked to Alzheimer's change in people with mild cognitive impairment. It is a Phase 2 trial, meaning it is exploring whether the approach works and is safe, not yet proven or approved.
Eligibility criteria
Inclusion Criteria: Individuals with mild cognitive impairment (MCI Group) Inclusion Criteria: * Age 18-85 years * MCI subjective criteria: self- or informant-reported cognitive complaint * Objective cognitive impairment supported by one of the following measures of general cognitive function: (a) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the typical neuropsychological criteria for MCI diagnosis (1 score on any test at least1.5 SD below the mean); or (b) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the Jak/Bondi neuropsychological criteria for MCI diagnosis(2 scores at least 1 SD below the mean in one domain, or 3 scores at least 1SD below the mean across domains) * Right-handed * English speaking * Able to attend daily intervention and outcome measurements for ~15 days over a 6 month period. * Not enrolled in another interventional study within 6 months prior to beginning this study Exclusion Criteria: * Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI) * Reported sudden or steep decline of cognitive performance * Telephone Interview for cognitive impairment (TICS) score * Other neurological disorders (e.g., stroke, head injuries, or multiple sclerosis) * Psychiatric disorder (except stable late-life depression due to its high prevalence in MCI individuals) * Current cancer treatment or other comorbid/unstable medical conditions that might independently affect cognitive function
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-17