NCT07042087 · RECRUITING
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
This trial tests a nine-month program of mindful yoga, brain training, and time-restricted eating with nutrition counseling for a mostly plant-based diet. Researchers will track thinking skills, a blood marker of tau, fitness, and metabolism in older adults at higher Alzheimer's risk. It is not a drug study, and the phase is not applicable, so it is not testing a medicine for approval.
You may qualify if
- Age 60-80 years
- Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)
- mini-mental-scale (MMSE) score between 24-30
- Positive plasma pTau217 biomarker
- Stable dose of iAChE therapy (if applicable)
- Ability to participate in a 9-month intervention
You're excluded if
- Stroke or myocardial infarction within the past year
- Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)
- Long-term psychiatric treatment (except well-managed depression)
- Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)
- Severe sensory or motor impairment preventing protocol participation
- Active cancer treated within the past 5 years
- Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)
- Concurrent participation in another clinical study
- Unstable iAChE medication regimen
- Substance or alcohol dependence
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-06-27