NCT07025070 · RECRUITING
The Link Between Physical Activity and Brain Health in Healthy Adults
This is an observational study, so nobody is given a treatment. Researchers will compare former athletes who still exercise with sedentary people. They'll look at brain scans, memory and thinking tests, blood markers, and genetics to see whether an active life is linked to healthier brain structure. No phase applies.
You may qualify if
- Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
- Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
- In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
- Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition
You're excluded if
- Medical conditions that have a high risk of associated cognitive symptoms.
- Severe head injury with loss of consciousness within the previous 5 years.
- Alcoholism (>3 alcoholic drinks per day).
- Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
- Hearing or visual impairment that would preclude testing
- History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
- Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
- Presence of severe systemic disease (e.g., cancer under treatment).
- Consumption of anabolic substances.
- Problems understanding spoken or written Spanish.
- Those with pacemakers or metallic implants that may interfere with the MRI.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-06-17