NCT06661564 · RECRUITING
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
This pilot study collects a small sample of tears, plus a small blood sample, from people with mild cognitive impairment or Alzheimer's dementia and from healthy volunteers. Researchers will compare proteins (tau, amyloid) and fats in the tears to see if tears could someday help with diagnosis. It is an early, non-drug study with no phase, so it tests a method, not a treatment.
Eligibility criteria
Inclusion Criteria: * Age ≥18 years * Participant affiliated in French Social Security scheme * Informed and written consent from the participant Exclusion Criteria: * Pregnant or breastfeeding woman * Participant under judicial protection measures * Participant under guardianship or curatorship * Contraindications to participation in the research: Other neurodegenerative disease Any eye drops or treatment that may interfere with tear production Occasional or permanent contact lens use within the last 3 months Eye surgery ≤3 months Any ocular pathology other than refractive errors, oculomotor disorders, amblyopia Any general pathology other than AD with ocular implications -Inability to perform tear collection
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-07