NCT06470568 · ACTIVE NOT RECRUITING
Resistance Exercise Training in Individuals Aged 60 and Older With Mild Cognitive Impairment
This trial tests whether 12 weeks of progressive resistance exercise, like weight training, plus usual care improves thinking, muscle mass, and strength in adults 60 and older with mild cognitive impairment (MCI). It is compared with usual care alone. About 60 people are involved. It is not a drug trial, and the phase is not applicable.
You may qualify if
- Individuals with Mild Cognitive Impairment will be identified through the administration of the standard MoCA test and the Pfeffer Functional Activities Questionnaire (PFAQ). Both assessments will be conducted in a single evaluation session by an expert neurologist.
- 18.5 \< body mass index \<30 kg/m2
You're excluded if
- Performing regular resistance exercise training in the previous 6 months
- Unstable cardiac diseases, or individuals who have had a stroke in the last 6 months
- Significant psychiatric or neurological disorders, with the use of acetylcholinesterase inhibitors, and untreated mood disorders or depressive pathology
- Neuromuscular or mobility disorders that prevent safe resistance training (debilitating arthritis, spasticity/rigidity, and paralysis), along with untreated metabolic disorders (such as uncontrolled systemic hypertension)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-07