NCT06414967 · RECRUITING
Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)
This small pilot study is testing whether a digital music therapy tool, used alongside usual care, can ease irritability and impulsivity in 15 people with early-stage Huntington's disease. Everyone gets the music. It is a pilot with no phase label, so it is an early look at feasibility, not proof that it works.
You may qualify if
- Age >= 18 years
- Huntington disease genetically confirmed by the presence of at least 35 repeats of the CAG triplet in exon 1 of the HTT gene
- UHDRS (Unified Huntington's disease Rating Scale) score \<= 5 with a diagnostic confidence score =4
- Absence of significant cognitive impairment MoCA >=24
- Stable drug therapy in the 28 days prior inclusion and during the study
- Without legal tutors or subordination
- Affiliated to a health insurance system as required by the French law on biomedical research
- Written informed consent for participation in the study
You're excluded if
- Inability to give free and informed consent for study participation
- Significant hearing impairment
- Participating to another study the day of enrollement
- Persons benefiting from enhanced protection, i.e.persons deprived of their liberty by a judicial or administrative decision, adults under legal and finally patients in a vital emergency situation.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-29