NCT06182995 · ACTIVE NOT RECRUITING
Anticipating Decline and Providing Therapy
This trial tests a post-ICU support program called ADAPT against usual care for older adults who experienced delirium during a serious illness. The goal is to see whether early screening and structured follow-up can reduce cognitive decline after an ICU stay. This is a Phase NA pilot feasibility study, meaning researchers are checking whether the approach is practical and worth testing at larger scale — it is not yet proven or approved.
You may qualify if
- Age 60 and older at time of discharge from intensive care unit
- Minimum 72 hour Intensive Care Unit stay in an ICU at Atrium Health Wake Forest Baptist
- Delirium during ICU stay as determined by positive Confusion Assessment Method (CAM)-ICU score, review of clinical - documentation, or discussion with clinical team
- Primary care provider in the Atrium Health Wake Forest system or intention to follow with Primary Care Physician in Atrium Health system
- English speaking
You're excluded if
- Death during initial hospitalization and/or discharge to Hospice
- Life-expectancy \< 6 months from pre-existing illness (defined as diagnosis of metastatic cancer, cirrhosis, advanced heart failure, prior palliative care referral)
- Acute Traumatic Brain Injury
- Continued residence in skilled nursing facility or rehab that prevents ability to complete study telephone call at time of first cognitive screen attempt
- Prior history of dementia in electronic health record
- Language or communication barrier that prohibits intervention participation
- Participant cannot identify family or caregiver contact or family/caregiver unwilling to participate
- Subject or legally authorized representative (LAR) decline consent
- Unstable telephone service for contact after hospital discharge
- Primary residence outside of North Carolina
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-07-24